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[/et_pb_fullwidth_image][/et_pb_section][et_pb_section fb_built=”1″ use_custom_gutter=”on” gutter_width=”1″ specialty=”on” padding_left_1=”35px” padding_left_2=”35px” padding_2_tablet=”|||0px” padding_2_phone=”|||0px” padding_2_last_edited=”on|desktop” module_class_1=”sidebar-secondary-nav” module_class=”handprint-bg” _builder_version=”4.27.4″ background_image=”https://www.progeriaresearch.org/wp-content/uploads/2019/04/blue-handprint-only.png” parallax=”on” parallax_method=”off” inner_width=”100%” inner_max_width=”100%” custom_padding=”0|0px|0px|0px|false|false” z_index_tablet=”500″ border_width_top=”10px” border_color_top=”#8fd2ed” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_sidebar area=”et_pb_widget_area_32″ disabled_on=”off|off|off” admin_label=”Workshop 2025″ module_class=”subpage-sidebars” _builder_version=”4.27.4″ _dynamic_attributes=”link_option_url” animation_style=”fade” link_option_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wb3N0Iiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyODc3In19@” z_index_tablet=”500″ border_width_right=”5px” locked=”off” global_colors_info=”{}”][/et_pb_sidebar][/et_pb_column][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner custom_padding_last_edited=”on|phone” _builder_version=”4.16″ custom_padding=”39.4375px|35px|6px||false|false” custom_padding_tablet=”|35px||35px||true” custom_padding_phone=”” animation_direction=”top” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https://www.progeriaresearch.org/wp-content/uploads/2025/10/2025-PRF-Workshop-Agenda-10.28.25.pdf” button_text=” Agenda for The Progeria Research Foundation International Scientific Workshop ” button_alignment=”center” disabled_on=”off|off|off” admin_label=”Agenda pdf” _builder_version=”4.27.4″ _module_preset=”default” button_text_size=”25px” button_bg_color=”#FA9405″ button_border_radius=”50px” background_layout=”dark” custom_margin=”3px||30px||false|false” global_colors_info=”{}”][/et_pb_button][/et_pb_column_inner][/et_pb_row_inner][et_pb_row_inner _builder_version=”4.17.6″ _module_preset=”default” custom_padding=”38px|||||” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text disabled_on=”off|off|off” admin_label=”Agenda Wednesday” _builder_version=”4.27.4″ _module_preset=”default” header_text_color=”#000000″ custom_margin=”|25px|||false|false” custom_padding=”|0px||||” border_width_all=”4px” border_color_all=”#00B2E2″ box_shadow_style=”preset6″ global_colors_info=”{}”]
Agenda at a GlanceNote: Agenda Subject to Change |
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Wednesday, October 29, 2025 |
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| Time | Session | Speaker |
| 3:00-5:00 PM | Registration & Poster Set-Up | |
| 5:00-5:15 PM | Introduction & Greetings from PRF |
Audrey Gordon, Esq. Scott Berns, MD, MPH, FAAP Leslie Gordon, MD, PhD |
| 5:15-5:25 PM | PRF Medical Research Remarks | Leslie Gordon |
| 5:25-6:25 PM | “Coming of Age” Conversations: Young Adults with HGPS as Research Partners | Moderator: Merlin Waldron, USA Kaylee Halko, USA Amber Vandeweert-Wielemans, Belgium Michiel Vandeweert, Belgium Riccardo Zanolli, Italy |
| 6:25-6:35 PM | Musical Kickoff | Francis Collins, MD, PhD |
| 6:35-6:45 PM | Group Photo – All Attendees! | |
| 6:30 PM | Dinner & Collaborative Interaction Time | |
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Thursday, October 30, 2025 |
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| 7:45 AM-8:00 PM | Registration Desk Open | ||
| 8:00-9:00 AM | Bridging the Bench Mentor Session | ||
| 9:00-9:30 AM | Breakfast | ||
| Current Treatment Trial Outcomes in Progeria Moderator: Mark Kieran, MD, PhD, VP Clinical Development, Day One Biopharmaceuticals | |||
| 9:30-9:50 AM | New Trial: Disease Progression in Progeria | Leslie Gordon, MD, PhD | |
| 9:55-10:15 AM | Phase 2a Progerinin in Clinical Treatment Trial for Progeria | Monica Kleinman, MD Boston Children’s Hospital Harvard Medical School |
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| 10:20-10:40 AM | Tools for Pivotal Science and Medicine in Progeria: Biomarker Assay Development, Qualification and Reagent Generation | Barbara Natke, PhD Chief Business Officer and Biomarker Lead The Progeria Research Foundation |
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| 10:45-11:05 AM | Late-Stage Treatment of Aortic Stenosis in HGPS | Ashwin Prakash, MD Pediatric Cardiologist Boston Children’s Hospital |
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| 11:10-11:30 AM | Break | ||
| 11:35-11:50 AM | Late Breaking Presentation: A novel progerin-producing nonclassic HGPS phenotype: What progeria might look like with effective therapy | Linda Bulmer, MD Sahlgrenska University Hospital Gothenburg, Sweden |
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| 11:55 AM-12:20 PM | Poster Lightning Round | Poster Presenters | |
| 12:20-1:30 PM | Lunch and Collaborative Interaction Time | ||
| Cardiovascular Disease in HGPS and Aging Moderator: Maria Eriksson, PhD, Professor, Karolinska Institute | |||
| 1:30 -1:50 PM | New Autoptical Pathological findings Revealing HGPS Pathophysiology | Andrea Porzionato, PhD Professor University of Padova |
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| 1:55-2:15 PM | Single-cell Analysis Reveals the Phenotypic Landscape of Arterial Cells in Progeria | Maria Eriksson, PhD Lara Garcia Merino, MSc |
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| 2:20-2:40 PM | Evaluation of Coronary Artery and Aortic Calcium in Progeria by Computed Tomography | Sunil Ghelani, MD Attending Cardiologist Boston Children’s Hospital |
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| 2:45-3:05 PM | Angiopoietin-2: A Potential Therapeutic Target for Vascular Protection in Hutchinson-Gilford Progeria Syndrome | Lizzy Izydore, BS (for Kan Cao, PhD) University of Maryland |
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| 3:05-3:25 PM | Break | ||
| 3:25-3:45 PM | Bridging the gap: Translating CVpathology to clinical assessments and research study design | Keri Shafer, MD & Sheila Hegde, MD UT Southwestern Medical Center |
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| 3:50-4:10 PM | Progeria and Vascular Calcification: Diet and Treatments | Ricardo Villa Bellosta, PhD Group Leader, Ramon y Cajal Researcher Center for Research in Molecular Medicine and Chronic Diseases |
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| 4:15-4:25 PM | Poster Elevation – LRRK2 Knockdown Rescues Progerin-Induced Premature Aging | Lukas Mann Institute of Molecular Biology Mainz, Germany |
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| 4:25-4:35 PM | Poster Elevation – National Interview Survey for Patients with Hutchinson-Gilford Progeria Syndrome and Progeroid Laminopathies and Their Families in Japan | Yuko Okawa, MD Oita University, Japan |
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| 4:35 -5:30 PM | Break Adjourn Until Poster Session & Dinner | ||
| 5:30-6:30 PM | Poster Session Part 1 | Even Numbered Posters | |
| 6:00-7:00 PM | Dinner and Collaborative Interaction Time | ||
| 7:00-8:00 PM | Poster Session Part 2 | Odd Numbered Posters | |
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Friday, October 31, 2025 |
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| 7:30 AM-2:00 PM | Registration Desk Open | ||
| 7:30-8:30 AM | Breakfast & Networking | ||
| Progeria Treatment Discovery for a Healthy Future Moderator: Leslie Gordon | |||
| 8:30-8:50 AM | AI-driven Therapeutic Antisense Oligonucleotide for HGPS | Ning Shen, PhD Professor Liangzhu Laboratory, Zhejiang University School of Medicine |
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| 8:55-9:15 AM | Development of Gene Silencing (RNAi) and Gene Editing Therapeutics for Hutchinson-Gilford Progeria Syndrome (HGPS) | Nizar Saad, PhD Abigail Wexner Research Institute, Nationwide Children’s Hospital |
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| 9:20-9:45 AM | Mini Plenary: Cutting Edge Translational Gene Therapy | David Liu, PhD Thomas Dudley Cabot Professor of the Natural Sciences Howard Hughes Medical Institute Investigator Harvard University Broad Institute |
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| 9:50-10:10 AM | ProSPER: PROgeria Streamlined Platform Gene Editing for Rare Diseases | David Liu Francis Collins Leslie Gordon Meirui An, PhD, Broad Institute Mike Erdos, PhD, NHGRI |
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| 10:15-10:35 AM | First-Generation PROTACs for Improving Progeria Phenotype | Silvia Ortega Gutierrez, PhD Professor Universidad Complutense de Madrid |
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| 10:35-10:55 AM | Break | ||
| Endocrine and GI Disease in Progeria Moderator: Vicente Andrés, PhD, Professor, Centro Nacional de Investigaciones Cardiovasculares Carlos III | |||
| 10:55-11:15 AM | Lipodistrophy and Cardiovascular Pathology in HGPS | Vicente Andrés | |
| 11:20-11:40 AM | Unraveling Accelerated Intestinal Ageing in HGPS Physiopathology: An Integrative Approach | Laurence Arbibe, MD, PhD Director INSERM Institut Necker Enfants Malades |
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| 11:45-12:05 PM | Targeting Inflammation to Ameliorate HGPS Pathologies | Susana Gonzalo, PhD Professor St. Louis University School of Medicine |
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| 12:15-1:00 PM | Workshop Summary Session All Hands Discussion | Leslie Gordon and Francis Collins | |
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2025 PRF International Scientific Workshop Scientific Committee
Leslie B. Gordon, MD, PhD (Chair) – Medical Director, The Progeria Research Foundation; Professor of Pediatrics, Hasbro Children’s Hospital, Boston Children’s Hospital, and Harvard Medical School
Vicente Andres, PhD – Professor, Centro Nacional de Investigaciones Cardiovasculares Carlos III
Maria Eriksson, PhD – Professor, Karolinska Institute
Mark Kieran, MD, PhD – VP Clinical Development, Day One Biopharmaceuticals
2025 PRF International Scientific Workshop Planning Committee
Leslie B. Gordon, MD, PhD (Chair) – Medical Director, The Progeria Research Foundation; Professor of Pediatrics, Hasbro Children’s Hospital, Boston Children’s Hospital, and Harvard Medical School
Audrey Gordon, Esq – President and Executive Director, The Progeria Research Foundation
Gina Incrovato – Director of Operations, The Progeria Research Foundation
Darrien Marazzo – Clinical Trial Coordinator, The Progeria Research Foundation
Karen Gordon Betournay– Social Media and Website Coordinator, The Progeria Research Foundation
Elizabeth Maynard – Elizabeth Maynard, CMP, Meeting Planner, Etre Partners
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