The Progeria Research Foundation

For the Children ♥ For the Cure

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Vision

Our vision is a world in which every child with Progeria is cured.

Mission

To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.

Vision

Our vision is a world in which every child with Progeria is cured.

Mission

To discover treatments and the cure for Progeria and its aging-related disorders, including heart disease.

Progeria is an ultra-rare, fatal, “rapid-aging” disease that afflicts children who, without the FDA-approved treatment lonafarnib, die of heart disease at an average age of 14.5 years. PRF is the only non-profit organization solely dedicated to finding treatments and the cure for Progeria, and is making phenomenal progress toward that goal.

News

Mourning the loss of PRF Ambassador, Sammy Basso

The Progeria Research Foundation honors the life of Progeria researcher and advocate, Sammy Basso. Sammy sadly passed away at the age of 28 on October 5, 2024.

BIG NEWS: Announcing the launch of a brand-new clinical drug trial!

We’re back at it! PRF is thrilled to announce the start of a new Progeria clinical trial with a new drug called Progerinin.

New York Times | July 24, 2024: A Cure for Progeria Could be on the Horizon

The research is heating up: As reported in the New York Times, the cure for Progeria could be on the horizon!! Our collaborations with top minds in gene editing are paying off, and in the words of former NIH Director, Dr. Francis Collins, may be “the answer to a dream we all want to come true.”

PRF now collaborating with Sentynl Therapeutics, new global owner of lonafarnib treatment (Zokinvy©)

Effective Friday, May 3, Sentynl Therapeutics is responsible for the manufacture and distribution of Zokinvy, the FDA-approved treatment for Progeria.

PRF’s 12th International Scientific Workshop

Join us at our scientific workshop taking place at the Boston Marriott Cambridge Hotel, from October 29-31, 2025, to hear about the latest breakthroughs in Progeria research.

Get Involved

Our lonafarnib clinical trials enrolled 107 children from 42 different countries to test this now-FDA-approved treatment. Because of your support, these children and young adults are living longer, healthier lives.